Coinfection of Human Filarial Loa loa, Mansonnella perstans in Human T Lymphotropic Virus Type 1 Infected Individuals in Gabon - EHESP - École des hautes études en santé publique Access content directly
Journal Articles Advances in Clinical and Translational Research Year : 2020

Coinfection of Human Filarial Loa loa, Mansonnella perstans in Human T Lymphotropic Virus Type 1 Infected Individuals in Gabon

Abstract

A survey was conducted throughout Gabon to search simultaneously for Human T-Lymphotropic Virus type 1 (HTLV-1) using quantitative polymerase chain reaction (qPCR) and the serological method as well as filarial infection on the same sample by direct examination of 10 μL of blood and the concentration technique. 3728 samples were analyzed, showing that 8.3% (320/3728) were positive for HTLV-1, 22.3 % (831/3728) exhibited Loa loa and 9.8% (366/3728) were positive for Mansonella perstans. A total of 95 (2.5%) individuals had HTLV-1–L. Loa coinfection and 33 (0.9%) HTLV1–M. perstans coinfection. Interestingly, there were more carriers of L. loa microfilaria positive for HTLV-1 than L. loa-negative individuals (10.1% vs. 6.7%, respectively; p=0.0004). Regarding Mansonella perstans distribution (another filarial species prevalent in Gabon), there was no significant difference between HTLV-1 / M. perstans carriers and non-carriers (7.4% vs. 7.9%, respectively; p=0.77). Furthermore, a density of Loa loa microfilariae over 30,000 microfilariae per milliliter influences HTLV-1 carriage (p=0.02). The prevalence of L. loa, M. perstans microfilaremia and HTLV-1 monoinfections and coinfections was higher in forest ecosystems than in savannah and lakeland (p<0.001). Correlations were also found with age and sex. These results suggest that L. loa and not M. perstans microfilariae carriage may affect the carriage of HTLV-1. A relationship between sex, age, and the forest ecosystem is suggested.
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hal-04578246 , version 1 (21-05-2024)

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  • HAL Id : hal-04578246 , version 1

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Jean-Paul Akue, Berthold Bivigou-Mboumba, C. Padilla, Mirdad Kazanji, Dieudonné Nkoghe. Coinfection of Human Filarial Loa loa, Mansonnella perstans in Human T Lymphotropic Virus Type 1 Infected Individuals in Gabon. Advances in Clinical and Translational Research, 2020, 3, pp.100027. ⟨hal-04578246⟩
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