Lead Exposure in Infancy and Subsequent Growth in Beninese Children - EHESP - École des hautes études en santé publique Access content directly
Journal Articles Toxics Year : 2022

Lead Exposure in Infancy and Subsequent Growth in Beninese Children


Studies suggest that elevated postnatal blood lead levels (BLLs) are negatively associated with child growth. This study aimed to investigate the associations of childhood BLLs at age one year and growth outcomes at age six years (n = 661) in a cohort of children in Allada, Benin. The growth outcomes studied are weight-for-age Z-score (WAZ), height-for-age Z-score (HAZ), BMI-for-age Z-score (BMIZ), weight-for-height Z-score (WHZ), head circumference (HC), growth velocities, underweight, stunting, and wasting. Multivariable regression models examined the associations between BLLs and growth outcomes, with adjustment for potential confounders. The geometric mean BLLs was 59.3 μg/L and 82% of children had BLLs >35 μg/L at the age of 12.8 months. After adjusting for confounding factors, no overall association was found between BLL quartiles and HAZ, WAZ, BMIZ, WHZ, growth velocities, wasting, and underweight. However, boys in the highest quartile had a 1.02 cm lower HC (95% CI: [−1.81, −0.24]) as compared to the lowest quartile. Furthermore, an increased odds of being stunted was observed in children in the highest quartile of exposure compared to the first (OR: 2.43; 95% CI: [1.11–5.33]) which remained statistically significant only among girls in sex-specific strata. Blood lead was found to be associated with an increased risk of childhood stunting and a lower head circumference in a resource-limited setting.
Fichier principal
Vignette du fichier
toxics-10-00595.pdf (646.92 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-03826993 , version 1 (24-10-2022)



Shukrullah Ahmadi, Jérémie Botton, Roméo Zoumenou, Pierre Ayotte, Nadine Fievet, et al.. Lead Exposure in Infancy and Subsequent Growth in Beninese Children. Toxics, 2022, 10 (10), pp.595. ⟨10.3390/toxics10100595⟩. ⟨hal-03826993⟩
66 View
21 Download



Gmail Facebook X LinkedIn More