The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries - EHESP - École des hautes études en santé publique Access content directly
Journal Articles Psychological Medicine Year : 2017

The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries

J. Mcgrath
  • Function : Author
K. Mclaughlin
  • Function : Author
S. Saha
  • Function : Author
S. Aguilar-Gaxiola
  • Function : Author
A. Al-Hamzawi
  • Function : Author
J. Alonso
  • Function : Author
R. Bruffaerts
  • Function : Author
G. de Girolamo
  • Function : Author
P. de Jonge
  • Function : Author
O. Esan
  • Function : Author
S. Florescu
  • Function : Author
O. Gureje
  • Function : Author
J. Haro
  • Function : Author
C. Hu
  • Function : Author
E. Karam
  • Function : Author
S. Lee
  • Function : Author
J. Lepine
  • Function : Author
M. Medina-Mora
  • Function : Author
Z. Mneimneh
  • Function : Author
B. Pennell
  • Function : Author
M. Piazza
  • Function : Author
J. Posada-Villa
  • Function : Author
N. Sampson
  • Function : Author
C Lim
  • Function : Author
M. Viana
  • Function : Author
M. Xavier
  • Function : Author
E. Bromet
  • Function : Author
K. Kendler
  • Function : Author
R. Kessler
  • Function : Author

Abstract

Background: Although there is robust evidence linking childhood adversities (CAs) and an increased risk for psychotic experiences (PEs), little is known about whether these associations vary across the life-course and whether mental disorders that emerge prior to PEs explain these associations. Method: We assessed CAs, PEs and DSM-IV mental disorders in 23 998 adults in the WHO World Mental Health Surveys. Discrete-time survival analysis was used to investigate the associations between CAs and PEs, and the influence of mental disorders on these associations using multivariate logistic models. Results: Exposure to CAs was common, and those who experienced any CAs had increased odds of later PEs [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.9-2.6]. CAs reflecting maladaptive family functioning (MFF), including abuse, neglect, and parent maladjustment, exhibited the strongest associations with PE onset in all life-course stages. Sexual abuse exhibited a strong association with PE onset during childhood (OR 8.5, 95% CI 3.6-20.2), whereas Other CA types were associated with PE onset in adolescence. Associations of other CAs with PEs disappeared in adolescence after adjustment for prior-onset mental disorders. The population attributable risk proportion (PARP) for PEs associated with all CAs was 31% (24% for MFF). Conclusions: Exposure to CAs is associated with PE onset throughout the life-course, although sexual abuse is most strongly associated with childhood-onset PEs. The presence of mental disorders prior to the onset of PEs does not fully explain these associations. The large PARPs suggest that preventing CAs could lead to a meaningful reduction in PEs in the population.

Dates and versions

hal-03123811 , version 1 (28-01-2021)

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J. Mcgrath, K. Mclaughlin, S. Saha, S. Aguilar-Gaxiola, A. Al-Hamzawi, et al.. The association between childhood adversities and subsequent first onset of psychotic experiences: a cross-national analysis of 23 998 respondents from 17 countries. Psychological Medicine, 2017, 47 (7), pp.1230-1245. ⟨10.1017/S0033291716003263⟩. ⟨hal-03123811⟩
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