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Journal Articles Revue Neurologique Year : 2019

Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society

C. Lebrun (1) , S. Vukusic (2, 3) , V. Abadie , C. Achour , F. Ader (4) , H. Alchaar , A. Alkhedr , F. Andreux , G. Androdias , R. Arjmand , Bertrand Audoin (5) , D. Audry , D. Aufauvre , C. Autreaux , X. Ayrignac (6) , M. Bailbe , M. Benazet , C. Bensa , D. Bensmail , Eric Berger , P. Bernady , Y. Bertagna , D. Biotti , A. Blanchard-Dauphin , Jérémie Bonenfant (7) , M. Bonnan , B. Bonnemain , F. Borgel , E. Botelho-Nevers (8) , S. Boucly , Bertrand Bourre , C. Boutière (9) , P. Branger , D. Brassat (5) , S. Bresch (10) , V. Breuil (11) , Bruno Brochet (5) , H. Brugeilles , P. Bugnon , Philippe Cabre , Jean-Philippe Camdessanché , C. Carra-Dalière , Olivier Casez , J.-M. Chamouard , B. Chassande , P. Chataignier , M. Chbicheb , A. Chenet (12) , Jonathan Ciron , Pierre Clavelou (5) , M. Cohen , R. Colamarino , N. Collongues (5) , I. Coman , P.-R. Corail , S. Courtois , M. Coustans (13) , Alain Créange (14) , E. Creisson , N. Daluzeau , C. Davenas , J. de Seze (5) , Marc Debouverie (15) , R. Depaz , N. Derache , L. Divio , X. Douay , C. Dulau , F. Durand-Dubief (16) , G. Edan (13) , Z. Elias , O. Fagniez , M. Faucher , J.-M. Faucheux , M. Fournier (17) , A. Gagneux-Brunon (8) , P. Gaida , P. Galli , P. Gallien , J. Gaudelus (18) , D. Gault (19) , A. Gayou , M. Genevray , A. Gentil , J. Gere , L. Gignoux , M. Giroux , P. Givron , O. Gout (20) , J. Grimaud , A.-M. Guennoc , N. Hadhoum , P. Hautecoeur , Olivier Heinzlef , M. Jaeger , S. Jeannin , L. Kremer (21) , A. Kwiatkowski , Pierre Labauge (5) , Céline Labeyrie , S. Lachaud , I. Laffont (22) , C. Lanctin-Garcia , J. Lannoy , L. Lanotte , David A. Laplaud (23) , D. Latombe , M. Lauxerois , Emmanuelle Le Page (7) , Christine Lebrun-Frenay (24) , P. Lejeune , P. Lejoyeux , B. Lemonnier , Emmanuelle Leray (25, 26, 27) , C.-M. Loche , C. Louapre (28) , Catherine Lubetzki (29) , A. Maarouf (5) , B. Mada , L. Magy (5) , E. Maillart (30) , E. Manchon , R. Marignier (3) , P. Marque , G. Mathey (15) , A. Maurousset , C. Mekies , M. Merienne (21) , L. Michel , A.-M. Milor , X. Moisset (31) , Alexis Montcuquet , Thibault Moreau , N. Morel , M. Moussa , J.-P. Naudillon , M. Normand , P. Olive , J.-C. Ouallet , Olivier Outteryck , C. Pacault , C. Papeix (30) , Ivania Patry (32) , D. Peaureaux , Jean Pelletier (33) , B. Pichon (34) , S. Pittion , E. Planque , M.-C. Pouget , V. Pourcher (30) , C. Radot , I. Robert , F. Rocher , A. Ruet (35) , C. Saint-Val , J.-Y. Salle , A. Salmon , E. Sartori , S. Schaeffer , B. Stankhof , F. Taithe (36) , Eric Thouvenot (5) , C. Tizon , Ayman Tourbah (37) , P. Tourniaire , M. Vaillant (38) , Patrick Vermersch (5) , S. Vidil , A. Wahab , M.-H. Warter , S. Wiertlewski (39) , B. Wiplosz , B. Wittwer , C. Zaenker , H. Zephir (5)
1 UniCA - Université Côte d'Azur
2 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
3 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
4 Hosp Civils Lyon, Serv Malad Infect, Lyon, France
5 CRMBM - Centre de résonance magnétique biologique et médicale
6 CHU Montpellier
7 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]
8 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
9 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM]
10 CDHR CENTRE-VAL-DE-LOIRE - Comité de développement horticole de la région Centre-Val-de-Loire
11 GéPITOS - Génétique, physiopathologie et ingénierie du tissu osseux
12 SECM - Service d'Etudes du Comportement des Matériaux de Conditionnement
13 Service de Neurologie [Rennes] = Neurology [Rennes]
14 ENT - Excitabilité nerveuse et thérapeutique
15 APEMAC - Maladies chroniques, santé perçue, et processus d'adaptation
16 RMN et optique : De la mesure au biomarqueur
17 Combustion Research Facility
18 Service de Pédiatrie [Jean Verdier]
19 Kuriwa Observatory
20 Fondation Ophtalmologique Adolphe de Rothschild [Paris]
21 IBCP - Institut de biologie et chimie des protéines [Lyon]
22 EuroMov - Euromov
23 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie
24 UNS UFR Médecine - Université Nice Sophia Antipolis - Faculté de Médecine
25 REPERES - Recherche en Pharmaco-épidémiologie et Recours aux Soins
26 EHESP - École des Hautes Études en Santé Publique [EHESP]
27 METIS - Département Méthodes quantitatives en santé publique
28 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
29 Biologie des Interactions Neurones / Glie
30 CHU Pitié-Salpêtrière [AP-HP]
31 Service de Neurologie [CHU Clermont-Ferrand]
32 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
33 LAGEP - Laboratoire d'automatique et de génie des procédés
34 UL - Université de Lorraine
35 Haras National Suisse
36 CHU Clermont-Ferrand
37 CHU Reims - Hôpital universitaire Robert Debré [Reims]
38 Center for health studies
39 Service de neurologie [Nantes]
V. Abadie
  • Function : Author
C. Achour
  • Function : Author
H. Alchaar
  • Function : Author
A. Alkhedr
  • Function : Author
F. Andreux
  • Function : Author
G. Androdias
  • Function : Author
R. Arjmand
  • Function : Author
D. Audry
  • Function : Author
D. Aufauvre
  • Function : Author
C. Autreaux
  • Function : Author
X. Ayrignac
M. Bailbe
  • Function : Author
M. Benazet
  • Function : Author
C. Bensa
D. Bensmail
  • Function : Author
Eric Berger
  • Function : Author
P. Bernady
  • Function : Author
Y. Bertagna
  • Function : Author
D. Biotti
  • Function : Author
A. Blanchard-Dauphin
  • Function : Author
M. Bonnan
  • Function : Author
B. Bonnemain
  • Function : Author
F. Borgel
  • Function : Author
S. Boucly
  • Function : Author
Bertrand Bourre
  • Function : Author
P. Branger
  • Function : Author
H. Brugeilles
  • Function : Author
P. Bugnon
  • Function : Author
Philippe Cabre
  • Function : Author
Jean-Philippe Camdessanché
C. Carra-Dalière
  • Function : Author
Olivier Casez
  • Function : Author
J.-M. Chamouard
  • Function : Author
B. Chassande
  • Function : Author
P. Chataignier
  • Function : Author
M. Chbicheb
  • Function : Author
Jonathan Ciron
M. Cohen
R. Colamarino
  • Function : Author
I. Coman
  • Function : Author
P.-R. Corail
  • Function : Author
S. Courtois
  • Function : Author
E. Creisson
  • Function : Author
N. Daluzeau
  • Function : Author
C. Davenas
  • Function : Author
R. Depaz
  • Function : Author
N. Derache
  • Function : Author
L. Divio
  • Function : Author
X. Douay
  • Function : Author
C. Dulau
  • Function : Author
Z. Elias
  • Function : Author
O. Fagniez
  • Function : Author
M. Faucher
J.-M. Faucheux
  • Function : Author
P. Gaida
  • Function : Author
P. Galli
  • Function : Author
P. Gallien
  • Function : Author
D. Gault
  • Function : Author
A. Gayou
  • Function : Author
M. Genevray
  • Function : Author
A. Gentil
  • Function : Author
J. Gere
  • Function : Author
L. Gignoux
  • Function : Author
M. Giroux
  • Function : Author
P. Givron
  • Function : Author
J. Grimaud
  • Function : Author
A.-M. Guennoc
  • Function : Author
N. Hadhoum
  • Function : Author
P. Hautecoeur
  • Function : Author
Olivier Heinzlef
  • Function : Author
M. Jaeger
  • Function : Author
S. Jeannin
  • Function : Author
A. Kwiatkowski
  • Function : Author
Céline Labeyrie
  • Function : Author
S. Lachaud
  • Function : Author
I. Laffont
  • Function : Author
C. Lanctin-Garcia
  • Function : Author
J. Lannoy
  • Function : Author
L. Lanotte
  • Function : Author
D. Latombe
  • Function : Author
M. Lauxerois
  • Function : Author
P. Lejeune
  • Function : Author
P. Lejoyeux
  • Function : Author
B. Lemonnier
  • Function : Author
C.-M. Loche
  • Function : Author
B. Mada
  • Function : Author
E. Manchon
  • Function : Author
P. Marque
  • Function : Author
  • PersonId : 955472
  • IdRef : 10886300X
A. Maurousset
  • Function : Author
C. Mekies
  • Function : Author
L. Michel
  • Function : Author
A.-M. Milor
  • Function : Author
Alexis Montcuquet
  • Function : Author
Thibault Moreau
  • Function : Author
N. Morel
  • Function : Author
M. Moussa
  • Function : Author
J.-P. Naudillon
  • Function : Author
M. Normand
  • Function : Author
P. Olive
  • Function : Author
J.-C. Ouallet
  • Function : Author
Olivier Outteryck
  • Function : Author
C. Pacault
  • Function : Author
C. Papeix
D. Peaureaux
  • Function : Author
S. Pittion
  • Function : Author
E. Planque
  • Function : Author
M.-C. Pouget
  • Function : Author
C. Radot
  • Function : Author
I. Robert
  • Function : Author
F. Rocher
  • Function : Author
A. Ruet
  • Function : Author
C. Saint-Val
  • Function : Author
J.-Y. Salle
  • Function : Author
A. Salmon
  • Function : Author
E. Sartori
  • Function : Author
S. Schaeffer
  • Function : Author
B. Stankhof
  • Function : Author
F. Taithe
  • Function : Author
C. Tizon
  • Function : Author
P. Tourniaire
  • Function : Author
S. Vidil
  • Function : Author
A. Wahab
  • Function : Author
M.-H. Warter
  • Function : Author
B. Wiplosz
  • Function : Author
B. Wittwer
  • Function : Author
C. Zaenker
  • Function : Author

Abstract

Objectives: To establish recommendations on immunization for patients with multiple sclerosis (MS).Background: Vaccines have been suspected in the past to trigger MS and relapses. With the extension of the immunoactive treatment arsenal, other concerns have been raised more recently about an increased risk of infection or a decreased effectiveness of immunization in immunosuppressed patients.Methods: The French Group for Recommendations into Multiple Sclerosis (France4MS) performed a systematic search of papers in Medline and other university databases (January 1975-June 2018). The RAND/UCLA appropriateness method was chosen to review the scientific literature and to formalize the degree of agreement among experts on 5 clinical questions related to immunization and MS. Readers from the steering committee conducted a systematic analysis, wrote a critical synthesis and prepared a list of proposals that were evaluated by a rating group of 28 MS experts. The final version of the recommendations was finally reviewed by a reading group of 110 health care professionals and classified as appropriate, inappropriate or uncertain.Results: Neurologists should verify the vaccination status as soon as MS is diagnosed and before disease-modifying treatments (DMTs) are introduced. The French vaccination schedule applies to MS patients and seasonal influenza vaccination is recommended. In the case of treatment-induced immunosuppression, MS patients should be informed about the risk of infection and the vaccination standards of the French High Council of Health should be applied. Live attenuated vaccines are contra-indicated in patients recently treated with immunosuppressive drugs, including corticosteroids; other vaccines can be proposed whatever the treatment, but their effectiveness may be partly reduced with some drugs.Conclusion: Physicians and patients should be aware of the updated recommendations for immunizations of patients with MS.

Dates and versions

hal-02546158 , version 1 (17-04-2020)

Identifiers

Cite

C. Lebrun, S. Vukusic, V. Abadie, C. Achour, F. Ader, et al.. Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society. Revue Neurologique, 2019, 175 (6), pp.341-357. ⟨10.1016/j.neurol.2019.04.001⟩. ⟨hal-02546158⟩
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