Amygdalar nuclei and hippocampal subfields on MRI: Test-retest reliability of automated volumetry across different MRI sites and vendors - Institut de Neurosciences des Systèmes Accéder directement au contenu
Article Dans Une Revue NeuroImage Année : 2020

Amygdalar nuclei and hippocampal subfields on MRI: Test-retest reliability of automated volumetry across different MRI sites and vendors

1 IRCCS - Centro San Giovanni di Dio, Fatebenefratelli, Brescia
2 LANE - Laboratory of Alzheimer’s Neuroimaging and Epidemiology
3 UNITN - Università degli Studi di Trento = University of Trento
4 IRCCS SDN Napoli
5 Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
6 VU University Medical Center [Amsterdam]
7 UCL Queen Square Institute of Neurology
8 Clinical and experimental neuroimmunology [IDIBAPS]
9 Department of Radiology, IRCCS "Sacro Cuore-Don Calabria", Negrar, Verona
10 UNIVR - Università degli studi di Verona = University of Verona
11 INS - Institut de Neurosciences des Systèmes
12 UNICH - Universita' degli Studi "G. d'Annunzio" Chieti-Pescara
13 Interbalkan Medical Center of Thessaloniki
14 Universität Duisburg-Essen = University of Duisburg-Essen [Essen]
15 Perugia General Hospital
16 ToNIC - Toulouse NeuroImaging Center
17 Leipzig University / Universität Leipzig
18 Department of Radiology and Nuclear Medicine [Amsterdam]
19 LilNCog - Lille Neurosciences & Cognition - U 1172
20 Department of Psychiatry and Psychotherapy, Faculty of Medicine
21 UniGe - Università degli studi di Genova = University of Genoa
22 UNIPG - Università degli Studi di Perugia = University of Perugia
23 CRMBM - Centre de résonance magnétique biologique et médicale
24 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM]
25 IRCCS San Raffaele Pisana - Istituto di Ricovero e Cura a Carattere Scientifico
26 UMG - University Medical Center Göttingen
27 LIN - Leibniz Institute for Neurobiology [Magdeburg]
28 DZNE - Deutsches Zentrum für Neurodegenerative Erkrankungen [Ulm]
29 Aristotle University of Thessaloniki
30 Maastricht University [Maastricht]
31 Universidade de Aveiro
32 GSK - GlaxoSmithKline [Stevenage, UK]
33 Laboratory of Neuroimaging of aging, Memory clinic and LANVIE
Marco Aiello
  • Fonction : Auteur
Olivier Blin
Mira Didic
Hélène Gros-Dagnac
  • Fonction : Auteur
  • PersonId : 1370060
  • IdRef : 068901356
Pierre Payoux
Marco Salvatore
  • Fonction : Auteur
Roberto Tarducci

Résumé

Background: The amygdala and the hippocampus are two limbic structures that play a critical role in cognition and behavior, however their manual segmentation and that of their smaller nuclei/subfields in multicenter datasets is time consuming and difficult due to the low contrast of standard MRI. Here, we assessed the reliability of the automated segmentation of amygdalar nuclei and hippocampal subfields across sites and vendors using FreeSurfer in two independent cohorts of older and younger healthy adults. Methods: Sixty-five healthy older (cohort 1) and 68 younger subjects (cohort 2), from the PharmaCog and CoRR consortia, underwent repeated 3D-T1 MRI (interval 1-90 days). Segmentation was performed using FreeSurfer v6.0. Reliability was assessed using volume reproducibility error (ε) and spatial overlapping coefficient (DICE) between test and retest session. Results: Significant MRI site and vendor effects (p ​< ​.05) were found in a few subfields/nuclei for the ε, while extensive effects were found for the DICE score of most subfields/nuclei. Reliability was strongly influenced by volume, as ε correlated negatively and DICE correlated positively with volume size of structures (absolute value of Spearman's r correlations >0.43, p ​< ​1.39E-36). In particular, volumes larger than 200 ​mm3 (for amygdalar nuclei) and 300 ​mm3 (for hippocampal subfields, except for molecular layer) had the best test-retest reproducibility (ε ​< ​5% and DICE ​> ​0.80). Conclusion: Our results support the use of volumetric measures of larger amygdalar nuclei and hippocampal subfields in multisite MRI studies. These measures could be useful for disease tracking and assessment of efficacy in drug trials.

Domaines

Imagerie
Fichier principal
Vignette du fichier
Quattrini_2020.pdf (3.86 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
licence

Dates et versions

hal-03500798 , version 1 (25-06-2024)

Licence

Identifiants

Citer

Giulia Quattrini, Michela Pievani, Jorge Jovicich, Marco Aiello, Núria Bargalló, et al.. Amygdalar nuclei and hippocampal subfields on MRI: Test-retest reliability of automated volumetry across different MRI sites and vendors. NeuroImage, 2020, 218, pp.116932. ⟨10.1016/j.neuroimage.2020.116932⟩. ⟨hal-03500798⟩
105 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More