Introduction/Background: The aim of this study is to assess and compare the physical self-concept score of women with endometriosis performing a regular PA and not performing any regular PA. As endometriosis affects the quality of life in women (1,2), they tend to have a negative image of their body (3). This relates closely to the physical self-concept which refers as the perception or evaluation of a person's physical abilities and physical appearance (4). The physical self-concept could be increased by physical activity (PA) (5). Methods/Methodology: French women with endometriosis were asked to respond to a questionnaire over physical perception. The questionnaire was passed online through a link and on paper at the endometriosis clinic of Paris Saint Joseph hospital to increase the number and diversity of respondents. The short form of the physical self-description questionnaire was used to measure physical self-concept. In total, 418 women completed the questionnaire. Among them, 289 women stated performing a regular PA (at least once a week), and 129 stated not performing any regular PA. Results: The physical self-concept score was significantly higher in the regular PA group compared to the group not performing any regular PA (p<0.05). All the scores for the physical self-concept sub-domains were significantly higher in the regular PA group compared to the group not performing any regular PA (p<0.05). Conclusions/Discussion: Performing a regular PA might increase the overall physical self-concept of women with endometriosis and all its subdomains. Therefore, it should be recommended to women with endometriosis to perform a regular PA to increase their body perception and the image they have of their body. References: 1. Facchin, F., Barbara, G., Saita, E., Mosconi, P., Roberto, A., Fedele, L., & Vercellini, P. (2015). Impact of endometriosis on quality of life and mental health : Pelvic pain makes the difference. Journal of Psychosomatic Obstetrics & Gynecology, 36(4), 135‐141. 2. Warzecha, D., Szymusik, I., Wielgos, M., & Pietrzak, B. (2020). The Impact of Endometriosis on the Quality of Life and the Incidence of Depression—A Cohort Study. International Journal of Environmental Research and Public Health, 17(10), 3641. 3. Sayer-Jones, K., & Sherman, K. A. (2023). “My body...tends to betray me sometimes” : A Qualitative Analysis of Affective and Perceptual Body Image in Individuals Living with Endometriosis. International Journal of Behavioral Medicine, 30(4), 543-554. 4. Fox, K. R., & Corbin, C. B. (1989). The Physical Self-Perception Profile : Devlopment and Preliminary Validation. Journal of Sport and Exercise Psychology, 11(4), 408-430. 5. Lemoyne, J., Valois, P., & Guay, F. (2015). Physical Self-concept and Participation in Physical Activity in College Students. Medicine & Science in Sports & Exercise, 47(1), 142-150.